by National Library of Canada = Bibliothèque nationale du Canada in Ottawa .
Written in English
|Series||Canadian theses = Thèses canadiennes|
|The Physical Object|
|Number of Pages||249|
Here we show that fibronectin is critical for the incorporation of LTBP1 and transforming growth factor-β (TGFβ) into the ECM of osteoblasts and fibroblasts. Immunolocalization studies suggested that fibronectin provides an initial scaffold that precedes and patterns LTBP1 deposition but that LTBP1 and fibronectin are later localized in Cited by: Fibronectin stimulates myofibroblast differentiation of lens epithelial cells. Adding –4 ng/ml exogenous (preactivated) TGFβ to subconfluent DCDMLs plated on laminin induces expression of established markers of epithelial–mesenchymal transition (EMT) and/or epithelial–myofibroblast transition (EMyT) after a >3-day treatment (Boswell et al., , ).Cited by: 4. Recent evidence suggests that the binding of growth factors to the extracellular matrix (ECM) 1 is a major mechanism for regulation of growth factor activity and plays a fundamental role in tissue morphogenesis and repair ().The latent transforming growth factor β-binding proteins (LTBPs) are members of a family of ECM proteins that are key regulators of transforming growth factor-βs . THE JOURNAL 0 by The American Society of Biological Chemists, Inc. OF BIOLOGICAL CHEMISTRY Vol. , No. 9, Issue of Ma pp. Printed in d.S.A. Transforming Growth [email protected] Stimulates the Expression of Fibronectin and .
Rational: Patent ductus arteriosus (PDA) and a coexisting left brachiocephalic artery originating from the descending aorta is an extremely rare anomaly of unknown etiology. Significance: This critical review focuses on interactions between cells, fibronectin (FN), and growth factors (GF). Recent Advances: Initially, the extracellular matrix (ECM) was thought to serve simply as a reservoir for GFs that would be released as soluble ligands during proteolytic degradation of ECM. This view was rather quickly extended by the observation that ECM could concentrate GFs. The ductus arteriosus (DA) connects the main pulmonary artery and the aorta in fetal circulation and closes spontaneously within days after birth in normal infants. transforming growth factor. Transforming growth factor-β 1 (TGF-β 1) increases synthesis of secreted protein, acidic and rich in cysteine (SPARC), as well as fibronectin (FN) and type I r, little is known about the regulatory mechanism of SPARC expression. We examined the effect of FN on SPARC expression by TGF-β 1 in cultures of human periodontal ligament cells (HPL cells).
Transforming growth factor-beta regulates increased ductus arteriosus endothelial glycosaminoglycan synthesis and a post-transcriptional mechanism controls increased smooth muscle fibronectin. Transforming growth factor-beta prot ein and messenger RNA expression is increased in the closing ductus arteriosus. Pediatr Res Vol, No.3, Mar pp Abstract. Transforming growth factor-β1 (TGF-β1) plays an important role in the fibrogenic process in the liver. The aim of the present study was to explore the action of TGF-β1 on fibronectin expression in rat hepatic stem-like cells and the underlying mechanisms. We confirmed that TGF-beta 1 increases the expression of fibronectin, an adhesive glycoprotein expressed during embryogenesis and tissue remodeling. Based upon the h period required for a maximal fibroproliferative response to dermal injections of TGF-beta 1, we exposed human fetal lung fibroblasts (IMR) to TGF-beta 1 for periods up to.